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The serum concentration of Ibrutinib can be increased when it is combined with Valproic Acid. Salbutamol and other ОІ 2 receptor agonists also increase the conductance of channels sensitive to calcium and potassium ions, leading to hyperpolarization and relaxation of bronchial smooth muscles. Its affinity for the SERT was reported in one study using human tissues to be 0. Counseling Patients About Sexual Issues: Drug-Induced Priapism". Donepezil may increase the bradycardic activities of Cloranolol. Trihexyphenidyl may also be used for purposes other than those listed in this medication guide.