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Children have this enzyme but some adults no longer form it and they are unable to digest lactose. Hyperammonemia should also be considered in patients who present with hypothermia <see>Warnings and Precautions (5. Food does not affect either the rate or extent of absorption of risperidone. Chlorpheniramine; Pseudoephedrine: (Major) Some data suggest that the efficacy of tamoxifen is reduced when coadministered with CYP2D6 inhibitors, such as chlorpheniramine. These differences were small and do not indicate a need for dosage adjustment of the drug in the elderly. Also, more so than other tetracyclines, minocycline can cause the rare condition of secondary intracranial hypertension which has initial symptoms of headache, visual disturbances, dizziness, vomiting, and confusion.