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-Both studies also demonstrated that the elimination of the two major metabolites was reduced in patients with renal impairment <see>Clinical Pharmacology (12. The therapeutic efficacy of Otamixaban can be decreased when used in combination with Desogestrel. While writing, focus on the point of the pen and move your eyes with its movements. This information should not be used to decide whether or not to take tinidazole or any other medicine. Concomitant use may result in decreased concentrations of the active metabolites of tamoxifen, which can compromise efficacy. Additionally, post-marketing surveillance has identified very rare cases of ventricular arrhythmias including TdP, usually in patients with severe underlying proarrhythmic conditions.
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